Among the notable natives of Lisbon (then New Lisbon) was Civil War general William T. H. Brooks, who commanded a division in the Army of the Potomac during the Siege of Petersburg in 1864.

Lisbon is located at 40°46′26″N 80°46′3″W / 40.77389°N 80.7675°W / 40.77389; -80.7675 (40.773874, -80.767553).

According to the United States Census Bureau, the village has a total area of 1.1 square miles (2.9 km²), all land.

As of the census of 2000, there were 2,788 people, 1,133 households, and 696 families residing in the village. The population density was 2,521.1 people per square mile (969.8/km²). There were 1,253 housing units at an average density of 1,133.0/sq mi (435.8/km²). The racial makeup of the village was 97.74% White, 0.90% African American, 0.22% Native American, 0.22% Asian, 0.04% Pacific Islander, 0.29% from other races, and 0.61% from two or more races. Hispanic or Latino of any race were 0.61% of the population.

There were 1,133 households out of which 30.1% had children under the age of 18 living with them, 46.5% were married couples living together, 11.9% had a female householder with no husband present, and 38.5% were non-families. 34.3% of all households were made up of individuals and 16.8% had someone living alone who was 65 years of age or older. The average household size was 2.37 and the average family size was 3.07.

In the village the population was spread out with 24.9% under the age of 18, 8.8% from 18 to 24, 27.8% from 25 to 44, 22.6% from 45 to 64, and 15.9% who were 65 years of age or older. The median age was 38 years. For every 100 females there were 89.7 males. For every 100 females age 18 and over, there were 87.0 males.

The median income for a household in the village was $27,841, and the median income for a family was $36,707. Males had a median income of $29,271 versus $19,826 for females. The per capita income for the village was $14,097. About 10.1% of families and 14.1% of the population were below the poverty line, including 13.4% of those under age 18 and 5.2% of those age 65 or over.

Lisbon's students start out at the McKinley Elementary School in downtown Lisbon. The school originally started out as a K-6 school but for the 2006-2007 school year it became a K-5 school. The high school, Lisbon David Anderson Jr. Sr. High School, is located uptown. It was renovated for the 2006-2007 school year.

The school's athletic teams are known as the Blue Devils. The most heavily followed athletic programs at Lisbon's high school are football and basketball. Most notable is Lisbon's 1995 Division V State Championship in football, the only such championship in that sport ever to be held by a Columbiana County school. The high school also features a relatively prominent golf program. Other sports include raquetball, track, swimming, cross country, baseball, softball, volleyball, and cheerleading.

Also included as a Lisbon, Ohio school is Beaver Local High School, Beaver Local Middle School and Columbiana County Career and Technical Center.